Co-administration of ezetimibe and simvastatin in acute myocardial infarction. Assessment of potential pharmacokinetic interactions of ezetimibe/simvastatin and extended-release niacin tablets in healthy subjects. Ezetimibe ameliorates early diabetic nephropathy in db/db mice. Prevention of cardiovascular comorbidities in uremic patients on chronic dialysis: metabolic derangements and cardiovascular risk. Cholesterol absorption as a target for the treatment of hypercholesterolemia. Gateways to clinical trials. Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia.
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Effect of alirocumab dose increase on LDL lowering and lipid goal attainment in patients with dyslipidemia. High-density lipoprotein and low-density lipoprotein therapeutic approaches in acute coronary syndromes. Design and baseline characteristics of the simvastatin and ezetimibe in aortic stenosis (SEAS) study. Longitudinal treatment patterns among US patients with atherosclerotic cardiovascular disease or familial hypercholesterolemia initiating lipid-lowering pharmacotherapy. Comparison of the effects of simvastatin vs. rosuvastatin vs. simvastatin/ezetimibe on parameters of insulin resistance. New Validated Stability-Indicating Rp-HPLC Method for Simultaneous Estimation of Atorvastatin and Ezetimibe in Human Plasma by Using PDA Detector. Systematic approach to conformational sampling for assigning absolute configuration using vibrational circular dichroism.
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Transient global amnesia-like episode due to mistaken intake of zolpidem: drug safety concern in the elderly. Change in cholesterol absorption and synthesis markers in patients with coronary heart disease after combination therapy with simvastatin plus ezetimibe. Combination therapy with ezetimibe and simvastatin to achieve aggressive LDL reduction. Effectiveness and tolerability of adding ezetimibe to niacin-based regimens for treatment of primary hyperlipidemia. Hyperlipidemia: Drugs for Cardiovascular Risk Reduction in Adults. The effect of ezetimibe, administered alone or in combination with simvastatin, on lymphocyte cytokine release in patients with elevated cholesterol levels. Critical review of non-statin treatments for dyslipoproteinemia.
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Comparative efficacy and adverse effects of the addition of ezetimibe to statin versus statin titration in chronic kidney disease patients. Microsomal transfer protein inhibitors, new approach for treatment of familial hypercholesterolemia, review of the literature, original findings, and clinical significance. Ezetimibe therapy: mechanism of action and clinical update. Interaction of single-dose ezetimibe and steady-state cyclosporine in renal transplant patients. Lipid-altering efficacy and safety of ezetimibe/simvastatin versus atorvastatin in patients with hypercholesterolemia and the metabolic syndrome (from the VYMET study). Profile of evolocumab and its potential in the treatment of hyperlipidemia. Ezetimibe use remains common among medical inpatients.
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Evolocumab for Treating Primary Hypercholesterolaemia and Mixed Dyslipidaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Combination therapy for dyslipidemia. Novel role of NPC1L1 in the regulation of hepatic metabolism: potential contribution of ezetimibe in NAFLD/NASH treatment. Change in the cholesterol metabolism associated with the combined inhibition of synthesis and absorption. Ezetimibe: from pharmacology to clinical trials. Statins and the cholesterol mortality paradox.
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Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies. Do We Know When and How to Lower Lipoprotein(a)? Clinical Implications of Switching Lipid Lowering Treatment from Rosuvastatin to Other Agents in Primary Care. Atherogenic dyslipidemia and combination pharmacotherapy in diabetes: recent clinical trials. Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy. Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease. The role of ezetimibe in the prevention of cardiovascular disease: where do we stand after ARBITER 6-HALTS.
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Pharmacovigilance and teratovigilance 2008. Ezetimibe--a new approach in hypercholesterolemia management. Effect of combination therapy of ezetimibe and rosuvastatin on regression of coronary atherosclerosis in patients with coronary artery disease. Ezetimibe. Determination of immuno-reactive rabbit apolipoprotein B-48 in serum by ELISA. Ezetimibe combined with simvastatin compared with simvastatin alone results in a greater suppression of oxidative stress and enhanced fibrinolysis in patients after acute coronary events. Effectiveness of ezetimibe alone or in combination with twice a week Atorvastatin (10 mg) for statin intolerant high-risk patients.
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Ezetimibe: a selective cholesterol absorption inhibitor. Gateways to clinical trials. Lipid lowering therapy in type 2 diabetes. Efficacy and safety of ezetimibe coadministered with lovastatin in primary hypercholesterolemia. Safety and effectiveness of ezetimibe in liver transplant recipients with hypercholesterolemia. Clinical outcome of statin plus ezetimibe versus high-intensity statin therapy in patients with acute myocardial infarction propensity-score matching analysis. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.
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Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9 deficiency. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Statin intolerance: diagnosis and remedies. Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption. Effects of rimonabant, as monotherapy and in combination with fenofibrate or ezetimibe, on plasma adipokine levels: a pilot study. Update of Clinical Trials of Anti-PCSK9 Antibodies. Hypolipidaemic drug treatment: yesterday is not gone yet, today is challenging and tomorrow is coming soon; let us combine them all.
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Simvastatin plus ezetimibe: combination therapy for the management of dyslipidaemia. Lipid-lowering agents in the management of nonalcoholic fatty liver disease. Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model. Non-cholesterol sterols and cholesterol metabolism in sitosterolemia. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. Influence of age, gender, and race on the efficacy of adding ezetimibe to atorvastatin vs. atorvastatin up-titration in patients at moderately high or high risk for coronary heart disease. Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance.