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Viagra is one of the best-known treatments for erectile dysfunction (ED). ED is caused by insufficient blood flow to the penis, resulting in the inability to maintain an erection. Viagra can dramatically enhance the quality of an erection by increasing blood flow to the penis. Its effect lasts for 4-6 hours. Viagra is widely known to treat PAH (pulmonary arterial hypertension).

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Also known as:  Sildenafil Citrate.

Description

Viagra is an anti-impotence drug which enables men to achieve and sustain an erection.

The active ingredient of Viagra is Sildenafil Citrate (PDE-5 inhibitor). In response to sexual arousal, Sildenafil Citrate stimulates the release of nitric oxide (NO) in the corpus cavernosum. Nitric oxide activates the lyase enzyme which is followed by increasing levels of cyclic guanosine monophosphate (cGMP). This cyclic nucleotide relaxes smooth muscles in blood vessels of the corpus cavernosum, increasing blood flow and thus inducing an erection.

Along with the treatment of erectile disorders, Viagra effectively prolongs sexual performance, preventing premature ejaculation (PE).

Sildenafil Citrate is also used in the treatment of PAH (pulmonary arterial hypertension).

Viagra is also known as Aphrodil, Caverta, Kamagra, Suhagra, Edegra, Erasmo, Penegra, Revatio, Supra, Silagra, Zwagra.

Viagra does not protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.

Dosage

Take one Viagra pill orally with a full glass of water, 30-60 minutes before sex.

The dosage depends on the overall health of the patient. Do not take more than one pill per day.

Take Viagra on an empty stomach, as fatty meals, grapefruit juice and alcohol can interfere with the effectiveness of the medication.

Overdose

If you take an overdose of Viagra, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

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Contraindications

Do not take Viagra if you are allergic to any of Viagra’s components.

Do not take Viagra if you are also using organic nitrates, nitrate drugs for chest pain or heart condition (e.g., nitroglycerin, isosorbide dinitrate and isosorbide mononitrate), nitrates as amyl nitrate or nitrite ("poppers").

Do not take Viagra if you take other medications to treat erectile dysfunction or pulmonary arterial hypertension, such as riociguat (Adempas).

Do not take Viagra if you are taking erythromycin, alpha-blockers, ketoconazole, itraconazole (Sporanox or Nizoral), ritonavir (Norvir) or indinavir (Crixivan).

Do not consume alcohol while using Viagra, as it can lower your blood pressure, causing dizziness and rapid heart rate (tachycardia).

Do not drive or operate machinery while taking the medication.

Contact you doctor or health care professional right away if your erection lasts longer than 4 hours or if it becomes painful.

Viagra does not protect you or your partner from sexually transmitted diseases or pregnancy.

Viagra can be dangerous for children and women.

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Comparison of angiogenic and proliferative effects of three commonly used agents for pulmonary artery hypertension (sildenafil, iloprost, bosentan): is angiogenesis always beneficial? Relaxant effects of selected sildenafil analogues in the rat aorta. Arterial hypotension and prerenal failure in an extremely preterm infant associated with oral sildenafil. Should patients be given an initial low test dose of sildenafil? The potential benefit of vacuum devices augmenting psychosexual therapy for erectile dysfunction: a randomized controlled trial. Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study. Comparison of erythropoietin and sildenafil protective role against ischemia/reperfusion injury of the testis in adult rats.

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Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Sildenafil improves microvascular O2 delivery-to-utilization matching and accelerates exercise O2 uptake kinetics in chronic heart failure. Pharmacotherapy for erectile dysfunction. The effects of sildenafil on human sperm function in healthy volunteers. Phosphodiesterase type 5 inhibitors for the management of erectile dysfunction: preference and adherence to treatment. The top 12 advances in vascular medicine. Sildenafil reduces bother associated with erectile dysfunction: pooled analysis of five randomized, double-blind trials.

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Bladder and erectile dysfunctions in the Type 2 diabetic Goto-Kakizaki rat. Directional reflectance analysis for identifying counterfeit drugs: Preliminary study. Treatment of high altitude pulmonary edema at 4240 m in Nepal. Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway. Impact of introduction of sildenafil on other treatment modalities for erectile dysfunction: a study of nationwide and local hospital sales. Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors. Effect of intravenous sildenafil on pulmonary hemodynamics and gas exchange in the presence and absence of acute lung injury in piglets.

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Beneficial effects of phosphodiesterase 5 inhibition in pulmonary hypertension are influenced by natriuretic Peptide activity. Sildenafil (Viagra) for treating male erectile dysfunction. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Recurrent epistaxis after treatment with tadalafil (Cialis). Simultaneous determination of sildenafil and its active metabolite UK-103,320 in human plasma using liquid chromatography-tandem mass spectrometry. Pulmonary arterial hypertension following pulmonary thromboembolism. In vitro and ex vivo toxicological testing of sildenafil-loaded solid lipid nanoparticles.

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Pulmonary vasodilator therapy and early postoperative outcome after modified Fontan operation. Beneficial effect of sildenafil following surgery for mitral stenosis complicated by pre-capillary pulmonary hypertension: report of two cases. The effect of the sildenafil citrate on cerebral vasospasm and apoptosis following experimental subarachnoid hemorrhage in rats. Cost Effectiveness of First-Line Oral Therapies for Pulmonary Arterial Hypertension: A Modelling Study. Is the sildenafil product information adequate to facilitate informed therapeutic decisions? Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: a pilot randomized blinded study. Treatment with sildenafil, bosentan, or both in children and young people with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome.

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Long survival of congenital alveolar capillary dysplasia patient with NO inhalation and epoprostenol: effect of sildenafil, beraprost and bosentan. Evaluation of the residual solvent content of counterfeit tablets and capsules. Sildenafil-associated nonarteritic anterior ischemic optic neuropathy. T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs. Viagra speeds contraceptive pill ok in Japan. Inhibitory effect of sildenafil on the human isolated seminal vesicle. Clinical use of phosphodiesterase-5 inhibitors in cardiopulmonary diseases: from experimental evidence to clinical application.

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