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Generic Periactin is used to relieve cold- and allergy-related symptoms such as hay fever, nasal inflammation, stuffy nose, red and inflamed eyes, hives, and swelling. Generic Periactin is approved by FDA. Generic Periactin blocks the effects of the naturally occurring chemical histamine in your body.

Other names for this medication:
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Similar Products:
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Also known as:  Cyproheptadine.


Generic Periactin is used to treat fever, nasal inflammation, stuffy nose, red and inflamed eyes, hives, swelling and other symptoms of cold and allergy.

Generic Periactin blocks the effects of the naturally occurring chemical histamine in your body.

Periactin is also known as Cyproheptadine, Ciplactin, Periactine, Ciproral.

Generic name of Generic Periactin is Cyproheptadine.

Brand name of Generic Periactin is Periactin.


Generic Periactin can be taken in tablets (4mg) and syrup. You should take it by mouth.

Take Generic Periactin by mouth with or without food.

Measure the syrup form of Generic Periactin with a special dose-measuring spoon or cup.

If you want to achieve most effective results do not stop taking Generic Periactin suddenly.


If you overdose Generic Periactin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Periactin overdosage: extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, seizure.


Store at room temperature between 15 to 30 degrees C (59 to 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Pharmacological characterisation of the dopamine-sensitive adenylate cyclase in cockroach brain: evidence for a distinct dopamine receptor. Bilastine: in allergic rhinitis and urticaria. Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH. Dynamism of cytoprotective and antisecretory drugs in patients with unhealed gastric and duodenal ulcers. New aspects of human chronopharmacology. Buy periactin. Effect of cyproheptadine on thyrotrophin and prolactin secretion in normal man.


Do not take Generic Periactin if you are allergic to Generic Periactin components.

Try to be careful with Generic Periactin if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Periactin can harm your baby.

Do not take cyproheptadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

Be careful in taking Generic Periactin if you have glaucoma or pressure in the eye, stomach ulcer, enlarged prostate, bladder problems, difficulty urinating, hyperthyroidism, hypertension, any problems with heart, asthma.

Be careful with taking Generic Periactin if you use anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion); anti-depression medications such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil); any other medications that make you feel drowsy, sleepy, or relaxed.

Avoid machine driving while taking Generic Periactin.

Avoid alcohol.

Do not stop taking Generic Periactin suddenly.

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Clinical characteristics of 41 children with cyclic vomiting syndrome. Head turning induced by unilateral intracaudate thyrotropin-releasing hormone (TRH) injection in the cat. Evaluation of product switching after a state Medicaid program began covering loratadine OTC 1 year after market availability. On the neurochemical basis of self-stimulation with midbrain raphe electrode placements. Miscellaneous treatments for neuroleptic-induced tardive dyskinesia. The effects of metergoline and other serotonin receptor antagonists on serum corticosterone in rats. Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test.

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Effects of azatadine maleate on subjective appraisal and psychomotor functions relevant to driving performance. Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. Modifications of histamine receptor signaling affect bone mechanical properties in rats. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma. Production of active and passive anaphylactic shock in the WBB6F1 mouse, a mast cell-deficient strain. Impact of desloratadine and loratadine on the crosstalk between human keratinocytes and leukocytes: Implications for anti-inflammatory activity of antihistamines.

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Effect of transdermal azatadine on reducing histamine-induced wheal area. Effective prophylactic therapy for cyclic vomiting syndrome in children using valproate. Toxicity of cyproheptadine. Side effects and accidental overdosage (author's transl). Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction. Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents. Effect of cyproheptadine and combinations of cyproheptadine and amphetamine on intermittently reinforced lever-pressing in rats. Prophylactic drugs and cytokine and leptin levels in children with migraine.

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Veratramine-induced behavior associated with serotonergic hyperfunction in mice. A multicentre study of loratadine, clemastine and placebo in patients with perennial allergic rhinitis. Serotonin and the ovarian hyperstimulation syndrome. Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation. Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats. Inhibition of human and rabbit liver steroid and xenobiotic UDP-glucuronosyltransferases by tertiary amine drugs--implications for adverse drug reactions. Effect of tryptophan and selected analogues on body temperatur of endotoxin-poisoned mice.

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Evaluation of tricyclic antidepressant false positivity in a pediatric case of cyproheptadine (periactin) overdose. Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma. Primary acquired cold urticaria. Double-blind comparative study of treatment with cyproheptadine, chlorpheniramine, and placebo. Treating allergic rhinitis with second-generation antihistamines. Double-blind study of cetirizine and loratadine versus placebo in patients with allergic rhinitis. Drug-induced pancreatitis: a critical review. Modification of leech behavior patterns by reserpine-induced amine depletion.

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Therapeutic options in idiopathic chronic urticaria. Azatadine maleate/pseudoephedrine sulfate repetabs versus placebo in the treatment of severe perennial allergic rhinitis. Citalopram Overdose: a Fatal Case. Evidence for histamine and 5-hydroxytryptamine like effects of MK-212 on guinea pig ileum, taenia coli and rat fundus strip. Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats. Critical analysis of several analytical method validation strategies in the framework of the fit for purpose concept. Pharmacology of upper airways challenge.

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Management of cancer anorexia/cachexia. Biogenic amine control of growth hormone secretion in the fetal and neonatal rat. The effect of ketotifen on nitric oxide synthase activity. Antigen-induced anaphylactic death in mice. Serotonin and the ovarian hyperstimulation syndrome. Over-the-counter self-medication leading to intracranial hypertension in a young lady. Nasal challenge with allergen leads to maxillary sinus inflammation.

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Participation of serotonin in development of morphine dependence in mice and rats. Efficacy and safety of an extended-release formulation of desloratadine and pseudoephedrine vs the individual components in the treatment of seasonal allergic rhinitis. Rupatadine and levocetirizine for seasonal allergic rhinitis: a comparative study of efficacy and safety. Rupatadine in allergic rhinitis and chronic urticaria. Headshaking in a 10-year-old Thoroughbred mare. Chromosome studies on human fibroblast cultures following exposure to cyproheptadin. The effect of loratadine on activated cells of the nasal mucosa in patients with allergic rhinitis.

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Rupatadine: global safety evaluation in allergic rhinitis and urticaria. Influence of galanin and serotonin on the endocrine response to Hexarelin, a synthetic peptidyl GH-secretagogue, in normal women. Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore. Mechanisms of the modulating effect of mast cells on the leukocytic response in inflammation. The combined luminol/isoluminol chemiluminescence method for differentiating between extracellular and intracellular oxidant production by neutrophils. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Primary hyperaldosteronism.

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Psychogenic Itch Management. Toward the definition of childhood migraine. Antidepressant activities of WEB 1881, a new nootropic agent. Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice. Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat. Serotonin syndrome--several cases of this often overlooked diagnosis.

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The role of dopamine and serotonin in the discriminative stimulus effects of lisuride. The role of mast cells in the elicitation of experimental allergic encephalomyelitis. Effects of environmental factors on the development of insulin-dependent diabetes mellitus. Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine. Design, synthesis and biological activity evaluation of desloratadine analogues as H1 receptor antagonists. A retrospective, open-label analysis of the population pharmacokinetics of a single 10-mg dose of loratadine in healthy white Jordanian male volunteers. Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.

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