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Structural insights into Resveratrol's antagonist and partial agonist actions on estrogen receptor alpha. Multicentre randomised phase III trial comparing Tamoxifen alone or with Transarterial Lipiodol Chemoembolisation for unresectable hepatocellular carcinoma in cirrhotic patients (Fédération Francophone de Cancérologie Digestive 9402). Synuclein gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor (ER)-alpha36, a variant of ER-alpha. Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. Prognostic Impact of the Combination of Recurrence Score and Quantitative Estrogen Receptor Expression (ESR1) on Predicting Late Distant Recurrence Risk in Estrogen Receptor-Positive Breast Cancer After 5 Years of Tamoxifen: Results From NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-28 and B-14. Estrogenic control of mitochondrial function and biogenesis. Perinatal taurine imbalance alters the interplay of renin-angiotensin system and estrogen on glucose-insulin regulation in adult female rats. A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1.
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Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse. Estrogen receptor alpha phosphorylated at tyrosine 537 is associated with poor clinical outcome in breast cancer patients treated with tamoxifen. Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis. Synchronous bilateral breast cancer in a male. Longitudinal trends in utilization of endocrine therapies for breast cancer: an international comparison. Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. Optical coherence tomography study in tamoxifen maculopathy.
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Insights into sick sinus syndrome from an inducible mouse model. Inducible gene manipulations in brain serotonergic neurons of transgenic rats. CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial. Chemotherapy pro-drug activation by biocatalytic virus-like nanoparticles containing cytochrome P450. Luteinising hormone releasing hormone agonists (LH-RHa) in premenopausal early breast cancer patients: current role and future perspectives. Nanomolar dose of bisphenol A rapidly modulates spinogenesis in adult hippocampal neurons. Raloxifene and tibolone in elderly women: a randomized, double-blind, double-dummy, placebo-controlled trial. Estrogen directly modulates circadian rhythms of PER2 expression in the uterus.
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Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: a gynecologic oncology group study. Computational molecular docking assessment of hormone receptor adjuvant drugs: Breast cancer as an example. In vitro delivery of anti-breast cancer agents directly via the mammary papilla (nipple). Inducible gene manipulations in serotonergic neurons. A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. A prospective assessment of musculoskeletal toxicity and loss of grip strength in breast cancer patients receiving adjuvant aromatase inhibitors and tamoxifen, and relation with BMI. Differential oestrogen receptor binding is associated with clinical outcome in breast cancer. Heparanase procoagulant activity is elevated in women using oral contraceptives.
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Ocular findings in breast cancer patients using tamoxifen. A mouse tool for conditional mutagenesis in ovarian granulosa cells. Unusual causes of intrahepatic cholestatic liver disease. Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats. 17beta-Estradiol decreases vulnerability to ventricular arrhythmias by preserving connexin43 protein in infarcted rats. Awareness of preventive medication among women at high risk for breast cancer and their willingness to consider transdermal or oral tamoxifen: a focus group study. ClC-3 is a main component of background chloride channels activated under isotonic conditions by autocrine ATP in nasopharyngeal carcinoma cells. Effects of tibolone on climacteric symptoms and quality of life in breast cancer patients--data from LIBERATE trial.
Male papillary breast cancer treated by wide resection and latissimus dorsi flap reconstruction: A case report and review of the literature. Respective contributions of diet and medium to the bioaccumulation of pharmaceutical compounds in the first levels of an aquatic trophic web. Endocrine therapy as adjuvant or neoadjuvant therapy for breast cancer: selecting the best agents, the timing and duration of treatment. Generation of a tenascin-C-CreER2 knockin mouse line for conditional DNA recombination in renal medullary interstitial cells. Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice. Elevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrence. Modification of gene expression induced by siRNA targeting of estrogen receptor alpha in MCF7 human breast cancer cells. Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98.
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Toremifene improves lipid profiles in men receiving androgen-deprivation therapy for prostate cancer: interim analysis of a multicenter phase III study. Estrogen receptor alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity. Quantification of tamoxifen in pharmaceutical formulations using micellar liquid chromatography. Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. Reciprocal regulation of 17beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer. Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis. COUP-TFII inhibits NFkappaB activation in endocrine-resistant breast cancer cells. Making stem cell lines suitable for transplantation.
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High-resolution optical coherence tomography findings in solar maculopathy and the differential diagnosis of outer retinal holes. A systematic comparison of three commercial estrogen receptor assays in a single clinical outcome breast cancer cohort. Reducing the risk of distant metastases in breast cancer patients: role of aromatase inhibitors. Tamoxifen as first-line treatment in a premenarchal girl with juvenile breast hypertrophy. Adherence to adjuvant endocrine therapy for breast cancer: importance in women with low income. The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. Drug insight: breast cancer prevention and tissue-targeted hormone replacement therapy. Quantitative Analysis of Supporting Cell Subtype Labeling Among CreER Lines in the Neonatal Mouse Cochlea.
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Factors affecting uptake and adherence to breast cancer chemoprevention: a systematic review and meta-analysis. Omission of radiotherapy in elderly patients with early breast cancer: 15-Year results of a prospective non-randomised trial. Ospemifene 12-month safety and efficacy in postmenopausal women with vulvar and vaginal atrophy. Characterization of a tamoxifen-tethered single-walled carbon nanotube conjugate by using NMR spectroscopy. Investigating and critically appraising the expression and potential role of androgen receptor in breast carcinoma. Feasibility study of FDG PET as an indicator of early response to aromatase inhibitors and trastuzumab in a heterogeneous group of breast cancer patients. A phase I pharmacokinetics study of lapatinib and tamoxifen in metastatic breast cancer (EORTC 10053 Lapatam study). Antiangiogenic and hypolipidemic activity of coenzyme Q10 supplementation to breast cancer patients undergoing Tamoxifen therapy.
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Continuous tamoxifen and dose-dense temozolomide in recurrent glioblastoma. Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. The a"MAZE"ing world of lung-specific transgenic mice. Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. Phthalimido-ferrocidiphenol cyclodextrin complexes: Characterization and anticancer activity. In vitro effects of oestrogens, antioestrogens and SERMs on pancreatic solid pseudopapillary neoplasm-derived primary cell culture. A highly fluorescent AIE-active theranostic agent with anti-tumor activity to specific cancer cells. The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line.
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FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-treated breast cancer. The impact of adding radiation treatment after breast conservation surgery for ductal carcinoma in situ of the breast. Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. The role of selective estrogen receptor modulators on breast cancer: from tamoxifen to raloxifene. Antiproliferative effects of antiestrogens and inhibitors of growth factor receptor signaling on endometrial cancer cells. Antitumor/antiestrogenic effect of the chemokine interferon inducible protein 10 (IP-10) involves suppression of VEGF expression in mammary tissue. Null association between tamoxifen use and dementia in Danish breast cancer patients. Comparative analysis of the effects of estrogens and tamoxifen on the brain higher functions.
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Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy? Postmenopausal osteoporosis. ERβ-mediated estradiol enhances epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine. Tamoxifen-associated skin reactions in breast cancer patients: from case report to literature review. Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells. Evaluation of the effect of paclitaxel, epirubicin and tamoxifen by cell kinetics parameters in estrogen-receptor-positive ehrlich ascites tumor (eat) cells growing in vitro. Tamoxifen impairs both longitudinal and cortical bone growth in young male rats.