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Naprosyn is a drug which helps to fight with arthritis, menstrual cramps, tendinitis, bursitis, osteoarthritis, rheumatoid arthritis, juvenile arthritis, gouty arthritis, ankylosing spondylitis and its symptoms (inflammation, fever, pain and other). Naprosyn belongs to the group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs). Naprosyn works by blocking the action of enzyme called cyclooxygenase resulting in decreased production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation.

Other names for this medication:
Aleve, Anaprox, EC-Naprosyn, Flanax Pain Reliever, Leader Naproxen Sodium, Midol Extended Relief, Naprelan 375, Naprolag, Naproxene, Naproxenum natricum, Naxopren, Relokap

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Advil, Motrin, Zorvolex, Clinoril, Orudis, Motrin IB, Orudis KT, Oruvail, Tolectin DS, Cambia, Lodine XL, Nalfon, Advil Liqui-Gels, Cataflam, Ansaid, Arthrotec, Feldene, Ibu-8, Indocin, Lodine, Nuprin, Sprix, Vimovo, Voltaren


Also known as:  Naproxen.


Naprosyn is a drug which helps to fight with arthritis, menstrual cramps, tendinitis, bursitis, osteoarthritis, rheumatoid arthritis, juvenile arthritis, gouty arthritis, ankylosing spondylitis and its symptoms (inflammation, fever, pain and other).

Naprosyn belongs to the group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs).

Naprosyn is also known as Aleve, Naprelan, Naprogesic.

Naprosyn works by decreasing hormones caused pain and inflammation.

Naprosyn can't be taken by children under 2 years.


Naprosyn is available in coated tablets (250 mg, 500 mg), extended-release tablets and in liquid forms which should be taken orally.

Extended-release tablets are usually taken once a day.

For arthritis treatment Naprosyn coated tablets and liquid forms should be taken twice a day.

For gouty arthritis treatment Naprosyn tablets and liquid forms should be taken every 8 hours.

It would be better to take Naprosyn with food or milk.

The dosage of Naprosyn depends on the type of your disease and health state.

Tablets should not be crushed or chewed. Swallow the tablet whole.

Naprosyn can't be taken by children under 2 years.

If you want to achieve most effective results do not stop taking Naprosyn suddenly.


If you overdose Naprosyn and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Naprosyn overdosage: excessive fatigue, heartburn, lightheadedness, confusion, feeling drowsy, problems with breathing, problems with urination, vomiting, pain of stomach, dyspepsia.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

Flow injection chemiluminescence determination of naproxen based on KMnO4-Na2SO3 reaction in neutral aqueous medium. Alterations in skin immune response throughout chronic UVB irradiation-skin cancer development and prevention by naproxen. Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2). Laparoscopic presacral neurolysis for endometriosis-related pelvic pain. Cross-reactions in patch testing and photopatch testing with ketoprofen, thiaprophenic acid, and cinnamic aldehyde. Buy naprosyn. Analgesia for outpatient surgery: placebo versus naproxen sodium (a non-steroidal anti-inflammatory drug) given before or after surgery.


Do not take Naprosyn if you are allergic to Naprosyn components.

Be careful with Naprosyn if you are pregnant, planning to become pregnant, or are breast-feeding. Naprosyn can pass into breast milk. Naprosyn can harm your baby.

Do not take Naprosyn before or after heart bypass surgery (CABG).

Be careful with Naprosyn if you are taking blood thinner (such as warfarin (Coumadin)); diuretics (such as furosemide (Lasix)); lithium (such as Lithobid, Eskalith); steroids (such as prednisone); aspirin or other NSAIDs (ketoprofen (such as Orudis), indomethacin (such as Indocin), diclofenac (such as Voltaren), etodolac (such as Lodine), naproxen (such as Naprosyn, Aleve), ibuprofen (such as Motrin, Advil); glyburide (such as DiaBeta, Micronase); cyclosporine (such as Sandimmune, Gengraf, Neoral); ACE inhibitor (enalapril (such as Vasotec), fosinopril (such as Monopril), benazepril (such as Lotensin), quinapril (such as Accupril), captopril (such as Capoten), trandolapril (such as Mavik), lisinopril (such as Zestril, Prinivil), ramipril (such as Altace), moexipril (such as Univasc), perindopril (such as Aceon); methotrexate (such as Trexall, Rheumatrex).

Elderly people should be careful with dosage of Naprosyn.

Be very careful with Naprosyn if you suffer from or have a history of heart, kidney or liver disease, asthma, bowel problems, nose polyps, diverticulosis, stomach ulcers, bleeding, blood clot, high blood pressure, stroke, congestive heart failure.

Avoid smoking while taking Naprosyn.

Avoid consuming alcohol.

Avoid taking aspirin if you are taking Naprosyn.

Protect your skin from the sun.

Be careful with Naprosyn if you are going to have a surgery (dental or other).

Naprosyn can't be taken by children under 2 years.

It can be dangerous to stop Naprosyn taking suddenly.

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Celecoxib for the treatment of pain and inflammation: the preclinical and clinical results. Methotrexate-induced optic neuropathy. Leukocytoclastic vasculitis associated with naproxen. Enantioselective esterification of racemic naproxen by lipases in organic solvent. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. Diacetylrhein, a new therapeutic approach of osteoarthritis.

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Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis. Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs. Controlled-release naproxen using micronized ethyl cellulose by wet-granulation and solid-dispersion method. Recovery from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced immunosuppression in A/J mice by treatment with nonsteroidal anti-inflammatory drugs. A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies. Photophysical probes to assess the potential of cholic acid aggregates as drug carriers.

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An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee. Non-steroidal anti-inflammatory drugs and slow-acting anti-rheumatic drugs in juvenile rheumatoid arthritis. Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib. Lipase-catalyzed esterification of (S)-naproxen ethyl ester in supercritical carbon dioxide. Recurrent macrophage activation syndrome since toddler age in an adolescent boy with HLA B27 positive juvenile ankylosing spondylitis. Chronic non-bacterial osteomyelitis in children.

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Development of HPLC Method for the Determination of Buspirone in Rat Plasma Using Fluorescence Detection and Its Application to a Pharmacokinetic Study. Sensitization of visceral afferents to bradykinin in rat jejunum in vitro. A prospective randomized study of the injurious effects of aspirin and naproxen on the gastroduodenal mucosa in patients with rheumatoid arthritis. The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. Naproxen-induced pseudoporphyria. A clinical and ultrastructural study. Effect of diclofenac-Na on 24-hour urinary excretion of creatinine, calcium, uric acid and glycosaminoglycans in adult patients with recurrent calcium oxalate nephrolithiasis.

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Elimination half-life and serum protein binding of the anti-rheumatism agent naproxen in kidney failure. Acne conglobata associated with spondyloarthropathy and ankylosis of the wrists. Acute Migraine Treatment. A multicentre double-blind investigation comparing nimesulide and naproxen in the treatment of minor sport injuries. Double-blind study of Naproxen in osteoarthritis of the knee joint. Pulmonary hemosiderosis with juvenile rheumatoid arthritis: a case report.

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Design and evaluation of a self-adhesive naproxen-loaded film prepared from a nanoparticle dispersion. Fecal blood loss during isoxicam and piroxicam administration for 28 days. How do parents of children with juvenile idiopathic arthritis (JIA) perceive their therapies? Chiral recognition of zinc(II) ion complexes composed of bicyclo[3.3.0] octane-2,6-diol and s-naproxen probed by collisional-induced dissociation. A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis. Oral analgesia for relieving post-caesarean pain.

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Novel Validated Stability-Indicating UPLC Method for the Estimation of Naproxen and its Impurities in Bulk Drugs and Pharmaceutical Dosage Form. Micellar acid-base potentiometric titrations of weak acidic and/or insoluble drugs. Celecoxib effectively treats patients with acute shoulder tendinitis/bursitis. Bullous photosensitivity to naproxen: "pseudoporphyria". Preparation of high solubilizable microemulsion of naproxen and its solubilization mechanism. Major pharmaceutical residues in wastewater treatment plants and receiving waters in Bangkok, Thailand, and associated ecological risks.

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