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Generic Lioresal is a qualitative medication which is taken in treatment of spasms of skeletal muscles and its symptoms such as rigidity, concomitant pain and clonus in the result of multiple sclerosis. It is also used to treat spinal cord diseases. Generic Lioresal effectiveness is in blocking the activity of nerves within the part of your brain that controls the relaxation of skeletal muscle.

Other names for this medication:
Alpha-baclofen, Apo-baclofen, Baclodrint, Baclofene, Baclofeno, Baclofenum, Baclon, Baclopar, Baclosal, Baclosan, Bamifen, Barambo, Befon, Bio-baclofen, Clofen, Colmifen, Diafen, Espast, Flexibac, Gabalon, Kemstro, Lebic, Liofen, Lioresal intratecal, Lioresyl, Lyflex, Miorel, Onelaxant, Pacifen, Pharmaclofen, Pms-baclofen, Ratio-baclofen, Solofen, Stelax, Vioridon

Similar Products:
Diazepam, Tizandine


Also known as:  Baclofen.


Generic Lioresal is a perfect remedy in struggle against spasms of skeletal muscles and its symptoms such as rigidity, concomitant pain and clonus in the result of multiple sclerosis. It is also used to treat spinal cord diseases.

Generic Lioresal effectiveness is in blocking the activity of nerves within the part of your brain that controls the relaxation of skeletal muscle. It is GABA (gamma-aminobutyric acid).

Lioresal is also known as Baclofen, Riclofen, Kemstro, Baclospas.

Generic name of Generic Lioresal is Baclofen.

Brand names of Generic Lioresal are Lioresal, Kemstro.


Starting dose for adults is 5 mg three times a day.

Take Generic Lioresal tablets of 10 mg and 20 mg orally.

Starting dose can be increased every three days to a max of 80 mg a day: 5 mg; after 3 days-10 mg; after 3 days-15 mg; after 3 days-20 mg.

Your dosage should not be over 80 mg.

It hasn't been researched yet how Generic Lioresal affects the children under 12 years.

If you want to achieve most effective results do not stop taking Generic Lioresal suddenly.


If you overdose Generic Lioresal and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of reach of children.

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Spasticity management in the child with spastic quadriplegia. The reduction in paired-pulse inhibition in the rat hippocampus by gabapentin is independent of GABA(B) receptor receptor activation. Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations. Effect of the GABAB agonist baclofen on dipyrone-induced delayed gastric emptying in rats. Buy lioresal.


Do not take Generic Lioresal if you are allergic to Generic Lioresal components.

Do not take Generic Lioresal if you're pregnant or you plan to have a baby, or you are a nursing mother.

Do not take Generic Lioresal together with other drugs which block the activity of nerves because it can cause a reduction in brain function.

Be careful with Generic Lioresal if you are taking tricyclic antidepressants (such asElavil, Sinequan) or with monoamine oxidase inhibitors (such as Nardil, Parnate).

It hasn't been researched yet how Generic Lioresal affects the children under 12 years.

Be careful with Generic Lioresal if you suffer from kidney disease, stroke, epilepsy.

Avoid alcohol.

Avoid machine driving.

Do not stop take it suddenly.

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Chronic intrathecal drug administration for the control of intractable pain. The movement disorder of reflex sympathetic dystrophy. Inhibition of N- and P/Q-type calcium channels by postsynaptic GABAB receptor activation in rat supraoptic neurones. Effect of antispastic drugs on rapid force generation of spastic muscle. Respiratory responses induced by blockades of GABA and glycine receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit. Effect of GABA and baclofen on gastric mucosal protective factors.

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Baclofen for narcolepsy with cataplexy: two cases. Activation of central GABAA-but not of GABAB-receptors rapidly reduces pituitary LH release and GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized rats. Pharmacotherapy of trigeminal neuralgia. Pharmacological management of tetanus: an evidence-based review. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.

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Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice. Calcium sensing properties of the GABA(B) receptor. Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal. Treatment of trigeminal neuralgia: use of baclofen in combination with carbamazepine. GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats. Baclofen: effects on evoked field potentials and amino acid neurotransmitter release in the rat olfactory cortex slice.

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GABA(A)-mediated toxicity of hippocampal neurons in vitro. Botulinum toxin type A for the treatment of the spastic equinus foot in cerebral palsy. Intrathecal Baclofen Therapy in a Child With Severe Scoliosis: Report of 2 Cases. G-Protein-coupled modulation of presynaptic calcium currents and transmitter release by a GABAB receptor. Intrathecal baclofen for postoperative analgesia after total knee arthroplasty. G(o) transduces GABAB-receptor modulation of N-type calcium channels in cultured dorsal root ganglion neurons.

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Potential roles of GABA receptors in morphine self-administration in rats. A pharmacological analysis of pentagastrin-modulated behavior evoked by stimulation of the ventromedial hypothalamus. Weight gain in children with hypertonia of cerebral origin receiving intrathecal baclofen therapy. Principles of pharmaceutical management of spastic hypertonia. Cycloheximide abolishes pertussis toxin-induced increase in glutamate release from cerebellar granule neurones. Role of Catheter's Position for Final Results in Intrathecal Drug Delivery. Analysis Based on CSF Dynamics and Specific Drugs Profiles.

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The action of GABA agonists and an antagonist on the frequency structure of the electrical activity of different brain formations in rats. Multidisciplinary View of Alcohol Use Disorder: From a Psychiatric Illness to a Major Liver Disease. Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABAergic neuronal system in the hippocampus. Effects of muscimol and baclofen on levels of monoamines and their metabolites in the El mouse brain. Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats. GABAergic modulation of striatal cholinergic interneurons: an in vivo microdialysis study.

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GABAB receptor mRNA in the raphe nuclei: co-expression with serotonin transporter and glutamic acid decarboxylase. Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives. General, kappa, delta and mu opioid receptor antagonists mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: reciprocal and regional interactions. Impaired function of GABA(B) receptors in tissues from pharmacoresistant epilepsy patients. GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels. Chronic (-)baclofen or CGP 36742 alters GABAB receptor sensitivity in rat brain and spinal cord.

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Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice. GABAB receptor mediated effects on central respiratory system and their antagonism by phaclofen. Epileptiform activity in microcultures containing small numbers of hippocampal neurons. Enantiomeric separation of baclofen by capillary electrophoresis tandem mass spectrometry with sulfobutylether-beta-cyclodextrin as chiral selector in partial filling mode. Co-localized adenosine A1 and gamma-aminobutyric acid B (GABAB) receptors of cerebellum may share a common adenylate cyclase catalytic unit. GABA uptake into isolated retinal Müller glial cells of the guinea-pig detected electrophysiologically.

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Pre- and postsynaptic glutamate receptors at a giant excitatory synapse in rat auditory brainstem slices. Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study. Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α2 adrenergic receptors. Electrodiagnostic findings in syringomyelia. GABAergic-serotonergic interactions in regulating lordosis. GABAB receptor-mediated contractile effects resistant to tetrodotoxin in isolated cat ileum.

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