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Buy Duphaston (Dydrogesterone)
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Buy Duphaston

Generic Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Generic Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Generic Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol.

Other names for this medication:
Climaston, Dabroston, Dufaston, Femoston, Terolut

Similar Products:
Clomid, Estrace, Premarin, Dostinex, Ortho Tri-Cyclen, Aygestin, Plan B, Ponstel, Parlodel, Fosamax

 

Also known as:  Dydrogesterone.

Description

Generic Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Generic Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Generic Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol.

Generic name of Generic Duphaston is Dydrogesterone.

Duphaston is also known as Dydrogesterone.

Brand name of Generic Duphaston is Duphaston.

Dosage

The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder.

In irregular cycles due to endogenous progesterone deficiency

Generic Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles.

In secondary amenorrhoea

Administration of Generic Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Generic Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle.

In dysfunctional uterine bleeding

The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding.

To stop bleeding: Generic Duphaston 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days.

To prevent heavy bleedings: Generic Duphaston 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle.

In post-menopausal complaints

If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy A?A?A? HRT), Generic Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced.

On continuous estrogen therapy: Generic Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month.

On cyclic estrogen therapy: Generic Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment.

If you want to achieve most effective results do not stop taking Generic Duphaston suddenly.

Overdose

If you overdose Generic Duphaston and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Duphaston overdosage: diarrhea, stomach pain, hot and dry skin, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma. Prevention of postmenopausal bone loss using tibolone or conventional peroral or transdermal hormone replacement therapy with 17beta-estradiol and dydrogesterone. Synthetic progestins medroxyprogesterone acetate and dydrogesterone and their binary mixtures adversely affect reproduction and lead to histological and transcriptional alterations in zebrafish (Danio rerio). Differential effects of progestins on the circulating IGF-I system. Buy duphaston. Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism.

Contraindications

Do not take Generic Duphaston if you are allergic to Generic Duphaston components.

It is unknown how Generic Duphaston affects pregnant women or nursing mother.

Do not take Generic Duphaston if you have undiagnosed vaginal bleeding or a history of thromboembolic disorders.

Be careful with Generic Duphaston if you have cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine, history of mental depression.

Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking.

Do not stop taking Generic Duphaston suddenly.

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Efficacy and tolerance of Menorest compared to Premarin in the treatment of postmenopausal women. A randomised, multicentre, double-blind, double-dummy study. Assessment of the potency of orally administered progestins in women. Low-dose hormone therapy in the perimenopause. Comparison of oral dydrogesterone with suppository vaginal progesterone for luteal-phase support in in vitro fertilization (IVF): A randomized clinical trial. Progestogens in the treatment of secondary amenorrhea.

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A Phase III randomized controlled trial comparing the efficacy, safety and tolerability of oral dydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization. Comparison of the action of 17 beta-estradiol and progestins with insulin-like growth factors-I/-II and transforming growth factor-beta 1 on the growth of normal adult human bone-forming cells. In vitro effects of estradiol, dydrogesterone, tamoxifen and cyclophosphamide on proliferation vs. death in human breast cancer cells. Differential effects of progestogens on breast cancer cell lines. Long-term effects of oral and transdermal hormone replacement therapy on plasma homocysteine levels.

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Cardiovascular risk factors during sequentially combined 17 beta oestradiol and dydrogesterone (Femoston); results from a one-year study in postmenopausal women. Dydrogesterone-induced hepatitis and autoimmune hemolytic anemia. Transdermal sequential and continuous hormone replacement regimens with estradiol and norethisterone acetate in postmenopausal women: effects on the endometrium. Apoptosis and proliferation in breast cancer cells, cultured in vitro: effects of SERMs. Efficacy and tolerance of Menorest compared to Premarin in the treatment of postmenopausal women. A randomised, multicentre, double-blind, double-dummy study.

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Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality. Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal women. A randomised comparison over 8 months of 100 micrograms and 200 micrograms twice weekly doses of transdermal oestradiol in the treatment of severe premenstrual syndrome. Comparative anti-glycation and α-glucosidase inhibition studies of microbial transformed compounds of dydrogesterone. Long-term effects of oral estradiol and dydrogesterone on carbohydrate metabolism in postmenopausal women.

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Oral dydrogesterone versus vaginal progesterone gel in the luteal phase support: randomized controlled trial. Endometrial cytosolic and nuclear progesterone receptors in the luteal phase defect. Effect of Progesterone, Its Hydroxylated and Methylated Derivatives, and Dydrogesterone on Lipid Bilayer Membranes. Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone. Progestagens and anti-progestagens for pain associated with endometriosis.

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Maintenance of pregnancy in ovariectomized rats with steroid analogs and the reproductive ability of the progeny. Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile. Endometrial, physical and psychological effects of postmenopausal oestrogen therapy with added dydrogesterone. Cross-reaction of contraceptive steroids in competitive binding assays of progesterone and estradiol. Biological responses of progestogen metabolites in normal and cancerous human breast.

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EMS - 5-9 business days, prices - USD 30.00, signature is required on delivery.
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