Efficacy of medical therapy for the reduction of heart failure events in patients with implanted cardioverter defibrillators. Effect of carvedilol on survival and hemodynamics in patients with atrial fibrillation and left ventricular dysfunction: retrospective analysis of the US Carvedilol Heart Failure Trials Program. β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma. Development of a capillary electrophoresis assay for the determination of carvedilol enantiomers in serum using cyclodextrins. Plasma brain natriuretic peptide as a novel therapeutic indicator in idiopathic dilated cardiomyopathy during beta-blocker therapy: a potential of hormone-guided treatment. Exercise does not affect plasma concentrations of (R)- and (S)-carvedilol. Formulation development of carvedilol compression coated tablet.
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Effects of carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure. PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS. Rationale and design of the carvedilol or metoprolol European trial in patients with chronic heart failure: COMET. The influence of beta-blockers on delayed memory function in people with cognitive impairment. A case of plastic bronchitis presenting 9 years after Fontan. Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs.
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Carvedilol-lisinopril combination therapy and endothelial function in obese individuals with hypertension. Effects of carvedilol as third-line add-on therapy on blood pressure and glucose metabolism in type 2 diabetic patients with chronic renal disease stage 3 and above. The role of beta-blockers in the treatment of cardiomyopathy and ischaemic heart failure. Peroxyl radical scavenging activity of the antihypertensive drug carvedilol. Formulation and evaluation of carvedilol melt-in-mouth tablet using mucoadhesive polymer and PEG-6-stearate as hydrophilic waxy binder. Carvedilol for prevention of atrial fibrillation after cardiac surgery: a meta-analysis. Chronotropic incompetence: real life observations of a theoretical concept.
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Simultaneous quantification of vortioxetine, carvedilol and its active metabolite 4-hydroxyphenyl carvedilol in rat plasma by UPLC-MS/MS: Application to their pharmacokinetic interaction study. Comparative effects of carvedilol vs bisoprolol for severe congestive heart failure. Pre-discharge initiation of beta-blocker therapy in elderly patients hospitalized for acute decompensation of chronic heart failure: an effective strategy for the implementation of beta-blockade in heart failure. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Carvedilol reduces ischaemic skeletal muscle necrosis. Effect of Consupren, Carvedilol and BL-443 on the composition of lactate dehydrogenase in tissues of rats with cyclosporin nephropathy. Carvedilol in hypertension.
In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilol. Carvedilol reduces elevated B-type natriuretic peptide in dialyzed patients without heart failure: cardioprotective effect of the beta-blocker. Clinical trials update from the European Society of Cardiology Heart Failure meeting 2009: CHANCE, B-Convinced, CHAT, CIBIS-ELD, and Signal-HF. Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat. Plasma renin activity testing to guide triple antirenin system drug therapy in a patient with difficult-to-treat hypertension. Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists. Carvedilol protects tubular epithelial cells from ischemia-reperfusion injury by inhibiting oxidative stress.
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An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists. Ionic liquid phase microextraction combined with fluorescence spectrometry for preconcentration and quantitation of carvedilol in pharmaceutical preparations and biological media. Economic impact of beta blockade in heart failure. The comparative effects of long-term carvedilol versus bisoprolol therapy on QT dispersion in patients with chronic heart failure. A comparison of carvedilol with atenolol in the treatment of mild-to-moderate essential hypertension. INT-CAR-07 (U.K.) Study Group. Left ventricular assist device and drug therapy for the reversal of heart failure. Inhibitory action of carvedilol, a novel alpha, beta-adrenoceptor antagonist, on catecholamine secretion and calcium influx in cultured bovine adrenal chromaffin cells.
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Switching from carvedilol to bisoprolol ameliorates adverse effects in heart failure patients with dizziness or hypotension. Carvedilol preserves endothelial junctions and reduces myocardial no-reflow after acute myocardial infarction and reperfusion. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activation. Experience with beta-blocker therapy in patients with advanced heart failure evaluated for HTx. Effects of bisoprolol fumarate on left ventricular size, function, and exercise capacity in patients with heart failure: analysis with magnetic resonance myocardial tagging. Multiparametric comparison of CARvedilol, vs. NEbivolol, vs. BIsoprolol in moderate heart failure: the CARNEBI trial. Random research.
β-Blocker carvedilol protects cardiomyocytes against oxidative stress-induced apoptosis by up-regulating miR-133 expression. Comparative efficacy of nebivolol versus carvedilol on left ventricular function and exercise capacity in patients with nonischemic dilated cardiomyopathy. A 12-month study. Functional competence of a partially engaged GPCR-β-arrestin complex. New evidence from the CAPRICORN Trial: the role of carvedilol in high-risk, post-myocardial infarction patients. Reversed-phase high-performance liquid chromatographic enantioresolution of six beta-blockers using dinitrophenyl-L-Pro-N-hydroxysuccinimide ester, N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate and twelve variants of Sanger's reagent as chiral derivatizing reagents. Carvedilol: a countermeasure to heart failure. Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action.
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Effect of carvedilol on venous return: a mechanism of reduction in blood pressure. Beneficial neurohormonal profiles of beta-blockades in chronic left heart failure. Distinctive effects of carvedilol in the non-infarct zone: remodelling of the ligated rat heart linked to oxidative stress. Carvedilol mitigates adverse effects of epinephrine during cardiopulmonary resuscitation. Parvovirus B19 infection associated with dilated cardiomyopathy in patients with previous anthracycline exposure. Beta-blocker use in systolic heart failure and dilated cardiomyopathy. Mucoadhesive bilayer buccal tablet of carvedilol-loaded chitosan microspheres: in vitro, pharmacokinetic and pharmacodynamic investigations.