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Cialis is a quick-acting medication taken for the treatment of erectile dysfunction (ED). Compared to other ED medications, Cialis provides dependable results quickly and is known to prevent PE (premature ejaculation). The effects can last for up to 36 hours allowing men to choose the optimum moment for sex. Cialis also significantly improves the symptoms of BPH (benign prostatic hyperplasia) and of PAH (pulmonary arterial hypertension).

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Also known as:  Tadalafil.

Description

Cialis is used to help men with erectile dysfunction to achieve and maintain a strong erection in response to sexual stimulation.

The active ingredient Tadalafil is a PDE-5 inhibitor, which works by blocking a chemical in the body, known as phosphodiesterase type 5. It increases blood flow to the penile area providing an erection. Tadalafil stimulates the release of nitric oxide (NO) in the corpus cavernosum in response to sexual stimulation. Nitric oxide activates the lyase enzyme which results in increased levels of cyclic guanosine monophosphate (cGMP). This relaxes smooth muscles in blood vessels of the corpus cavernosum, increasing blood flow and thus inducing an erection.

Cialis is the only PDE-5 inhibitor approved for the treatment of BPH (benign prostatic hyperplasia). By inhibiting PDE-5, Tadalafil allows for vasodilation and relaxation of the smooth muscle of the prostate and bladder, which thereby improves symptoms of BPH.

Cialis as a treatment of premature ejaculation (PE) is usually suggested only when men with premature ejaculation also seem to suffer from erectile dysfunction.

Tadalafil is also used in the treatment of PAH (pulmonary arterial hypertension).

Cialis is also known as Tadacip, Tadalis, Apcalis SX, Forzest.

Cialis does not protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.

Dosage

Take one Cialis pill orally with a full glass of water, 30 minutes before the planned sexual activity.

Do not take more than one pill a day.

The dosage depends on the overall health of the patient.

Cialis can be taken with or without food.

Overdose

If you take an overdose of Cialis, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

A randomized open-label trial with a crossover comparison of sexual self-confidence and other treatment outcomes following tadalafil once a day vs. tadalafil or sildenafil on-demand in men with erectile dysfunction. Clinical monograph for drug formulary review: erectile dysfunction agents. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Tadalafil enhances the neuroprotective effects of ischemic postconditioning in mice, probably in a nitric oxide associated manner. Buy cialis.

Contraindications

Do not take Cialis if you are allergic to any of Cialis’s components.

Do not take Cialis if you are also using organic nitrates, nitrate drugs for chest pain or heart condition (e.g., nitroglycerin, isosorbide dinitrate and isosorbide mononitrate), nitrates as amyl nitrate or nitrite ("poppers").

Do not take Cialis if you take other medication to treat erectile dysfunction or pulmonary arterial hypertension, such as riociguat (Adempas).

Do not take Cialis if you are taking erythromycin, alpha-blockers, ketoconazole, itraconazole (Sporanox or Nizoral), ritonavir (Norvir) or indinavir (Crixivan).

Do not consume alcohol while using Cialis, as it can lower your blood pressure, causing dizziness and rapid heart rate (tachycardia).

Do not drive or operate machinery while taking the medication.

Contact you doctor or health care professional right away if your erection lasts longer than 4 hours or if it becomes painful.

Cialis does not protect you or your partner from sexually transmitted diseases or pregnancy.

Cialis can be dangerous for children and women.

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Phosphodiesterase 5 inhibitors in the treatment of premature ejaculation. Protein kinase G1 α overexpression increases stem cell survival and cardiac function after myocardial infarction. Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Combining testosterone and PDE5 inhibitors in erectile dysfunction: basic rationale and clinical evidences. Minimal clinically important differences in the vaginal insertion and successful intercourse items of the sexual encounter profile. PDE5 inhibitors: targeting erectile dysfunction in diabetics.

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Stereochemistry of the tadalafil diastereoisomers: a critical assessment of vibrational circular dichroism, electronic circular dichroism, and optical rotatory dispersion. Patterns of switching phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction: results from the Erectile Dysfunction Observational Study. Analysis of prescriptions of alpha-blockers and phosphodiesterase 5 inhibitors from the urology department and other departments. New drugs of 2003. Efficacy and safety of tadalafil in the treatment of Latin American men with erectile dysfunction: results of integrated analyses. Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors.

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Efficacy of pentoxifylline and tadalafil in rat model of ischemic colitis. Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. Tadalafil, a further innovation in the treatment of sexual dysfunction. Phosphodiesterase 5 inhibitors: current status and potential applications. Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits. Tadalafil alleviates muscle ischemia in patients with Becker muscular dystrophy.

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Tadalafil is efficacious and well tolerated in the treatment of erectile dysfunction (ED) in men over 65 years of age: results from Multiple Observations in Men with ED in National Tadalafil Study in the United States. Time from dosing to sexual intercourse attempts in men taking tadalafil in clinical trials. New treatment options for erectile dysfunction. Pharmacologic and nonpharmacologic options. Construct validation of patient global impression of severity (PGI-S) and improvement (PGI-I) questionnaires in the treatment of men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. Drug-printing by flexographic printing technology--a new manufacturing process for orodispersible films. Tadalafil population pharmacokinetics in patients with erectile dysfunction.

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Erectile dysfunction: anatomical parameters, etiology, diagnosis, and therapy. Time from dosing to sexual intercourse attempts in men taking tadalafil in clinical trials. Potency, selectivity, and consequences of nonselectivity of PDE inhibition. Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms suggestive of benign prostatic hyperplasia in an international, randomised, parallel, placebo-controlled clinical trial. Does tadalafil prevent erectile dysfunction in patients undergoing radiation therapy for prostate cancer? Erectile dysfunction after therapy with metoprolol: the Hawthorne effect.

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The Effect of Tadalafil on Sexual Function, Urinary Function and Health-Related Quality of Life in Patients Treated with Brachytherapy. High altitude pulmonary edema: a pressure-induced leak. Treatment for erectile dysfunction based on patient-reported outcomes: to every man the PDE5 inhibitor that he finds superior. Cardiovascular effects of tadalafil. Headspace-gas chromatographic fingerprints to discriminate and classify counterfeit medicines. Detection of a tadalafil analogue as an adulterant in a dietary supplement for erectile dysfunction.

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The effects of three phosphodiesterase type 5 inhibitors on ejaculation latency time in lifelong premature ejaculators: a double-blind laboratory setting study. Low-dose testosterone undecanoate capsules combined with tadalafil for late-onset hypogonadism accompanied with ED. Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic-Banded Mini-Swine. PDE5 inhibitors: in vitro and in vivo pharmacological profile. Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement. A new methodology for detection of counterfeit Viagra® and Cialis® tablets by image processing and statistical analysis.

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Protective effect of endothelial nitric oxide synthase against induction of chemically-induced diabetes in mice. Phosphodiesterases (PDEs) and PDE inhibitors for treatment of LUTS. Rapid-screening detection of acetildenafils, sildenafils and avanafil by ion mobility spectrometry. Pharmacology of phosphodiesterase 5 inhibitors. Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study. A framework for selecting analytical techniques in profiling authentic and counterfeit Viagra and Cialis.

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Oral tadalafil on alternate days for erectile dysfunction that fails to respond to on-demand sildenafil: a report of 15 cases. Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms. Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles. Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects. Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction. Tadalafil - a therapeutic option in the management of BPH-LUTS.

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